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Given his previous history of tick bites, abrupt onset of symptoms following antibiotic administration and a negative septic screen, JHR was the most likely diagnosis

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Our results demonstrated a significant downregulation of the PI3K/AKT pathway ( p = 0.049) at one hour, and of mTOR ( p = 0.033 at one hour and p = 0.021 at two hours) following APAP treatment in wild-type mice (Fig