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Overall, while LC derivatives, notably ALC, show promise in lowering TMAO production and modifying gut microbiota composition, additional studies are needed to completely understand their effects

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A 2011 clinical study (phase III trial) has shown that a vaccine targeting a unique molecular structure on certain lymphoma cells improved disease-free survival in follicular lymphoma patients who were already in a minimal residual disease state (ie, had a complete response after 6 to 8 months of combination chemotherapy) (Schuster 2011)

However, studies have found that taking about 400 mg of choline as choline bitartrate (which is about 4Xs the amount of choline in Brain Health ) increased blood levels of TMAO by about 71% (Wilcox, Am J Med 2021) The Bottom Line on Brain Health Memory Plus Is It Worth It