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Comparison of three diuretic treatment strategies for patients with acute decompensated heart failure

In a phase 2 dose-finding trial, once-weekly Cagrilintide produced clinically meaningful weight loss about 10.8% at the 4.5 mg dose over 26 weeks with gastrointestinal effects the most common adverse events [1]

The study primarily examined the murine models to determine the ability of their livers to generate urea nitrogen (CUNS), an indicator of nitrogen metabolism efficiency

Preferential loss of abdominal fat observed, resembling the pattern seen with lowdose hGH therapy [10]

As of June 2026, AOD-9604 is listed as Nominated but Withdrawn , meaning it is no longer actively under Category 2 nomination