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E., McDonnell, M

Through inducing ROS production and activating JNK pathway, ISA can increase the antitumor effects of doxorubicin in colon cancers (thus lowering the cardiotoxicity of doxorubicin) (Wu F

Dubrovsky YV, Samsa WE, Kondratov RV (2010) Deficiency of circadian protein CLOCK reduces lifespan and increases age-related cataract development in mice

however, the drugs undergo extensive first-pass metabolism in the liver, with only about 50-60% of a dose of diclofenac sodium or diclofenac potassium reaching systemic circulation as unchanged drug