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Methods: 6-8 weeks old wild type or Prmt6 knockout female mice were subjected to gonadectomy, ovaries were removed through an incision just below the rib cage, the muscle layer sutured, and the incision closed with wound clips

however, it has not been approved for use in humans (Huber 1981)

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Berberine, a mitochondrial-targeting compound, can inhibit PINK1 promoter hypermethylation and enhance PINK1 expression, thereby promoting autophagy-lysosome pathway and alleviating mitochondrial dysfunction in AD models (Wang et al., 2023)

S4A, B), the number of germ cells (Fig