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However, in the presence of hypoxia and excess hemin exposure along with supraphysiological concentrations of cystine, we readily detected the ability of DMF in contributing cysteine availability (Fig

& Hall, S

The Warburg effect was first discovered as a feature of metabolic reprogramming in cancer cells, whereby cancer cells have increased glucose uptake, hyperactivated glycolysis, decreased oxidative phosphorylation (OXPHOS), and the accumulation of lactate, even in the presence of abundant oxygen and functioning mitochondria [64]