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Loss of the Nrf2 transcription factor causes a marked reduction in constitutive and inducible expression of the glutathione S-transferase Gsta1, Gsta2, Gstm1, Gstm2, Gstm3, and Gstm4 genes in the livers of male and female mice

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Treatment is based on suppressing excessive growth by some anti-biotherapy agents, locally effective for the intestines

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In this study, the levels of total iron, Fe 2+ , and Fe 3+ in the blood increased, suggesting that intestinal mucosal cells were damaged by intestinal I/R injury and ferroptosis occurred, and the iron in the cells was released into the blood, which increased the blood iron concentration