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Its established side effects in the clinical setting include dizziness, headache, restlessness, nausea, and, less commonly, serotonin syndrome when combined with other serotonergic drugs (Loane and Politis 2012)

The stopping GLP-1s guide uses four restart signals: more than 5% regain over eight weeks despite protocol adherence, rebounding visceral-fat markers, HbA1c above the pre-drug baseline, or declining strength