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Early intervention with TrkB partial agonist LM22A-4 increases parvalbumin-positive inhibitory synapses around cortical pyramidal neurons, upregulates Nav1.1 expression in interneurons, and reduces spontaneous seizures from 65 to 21%, demonstrating neurotrophic modulation of inhibitory synaptic plasticity (Gu et al., 2022

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As always, talk to a healthcare professional if you have existing health concerns or are on medications

Typical protocols include enzyme-activity assays and metabolic-flux studies in cell and tissue models

3 How effective the Code and the List are at preventing and catching athletes who have committed Anti-Doping Rule Violations (under the Code) is a point of contention within the sporting, legal and scientific communities