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In human A-T patient fibroblasts, RNA-immunoprecipitation assays unveiled an increased interaction between PKM2 and the c-Myc mRNA IRES region, hence an elevated c-Myc protein level was detected (Fig

Lee Moffitt Cancer Center & Research Institute, Tampa, FL, United States This article was submitted to Hematologic Malignancies, a section of the journal Frontiers in Oncology Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

The expression of both YAP and TAZ was elevated in multiple tumor types, including glioma cells, and was associated with the grade of malignancy, which was highest in GBM patients (139)

More recent studies characterized the iron-binding site on the KH3 domain of PCBP1

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