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ROS can also damage nucleic acids and cause DNAprotein crosslinking, strand breaking, and alteration in purine and pyridine bass structures, resulting in DNA mutations [26]

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It is noteworthy that an excessive dietary intake of methionine-rich animal protein is an additional cause of hyperhomocysteinemia detected both in the fasting state and after an oral methionine load, especially when tissue folate and cobalamin stores are intact