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Longevity Pathways To affect longevity, we must understand its pathways pathways Insulin/IGF-1 Signaling Metformin enhances insulin sensitivity and reduces IGF-1 activity, preventing overactive growth signaling that leads to abnormal cell proliferation

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Omega-3 fatty acids: Reduce systemic inflammation through multiple pathways

Blood levels of Vitamin A should be monitored periodically

Klimas NG, Broderick G, Fletcher MA