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10.1016/j.jmb.2022.167680 197 ZhengY.BonfiliL.WeiT.EleuteriA

T., & Lovly, C

143,144 The mutated IDH1 and IDH2 proteins are endowed with a novel ability to catalyze the reduction of -KG to generate a rare metabolite, 2-hydroxyglutarate (2-HG), while consuming NADPH

Looking back, I'm like, That was crazy! And it was soft when you walked on it

Therefore, the decreased OCLN expression observed in our study may reflect increased phosphorylation and subsequent internalization or degradation, rather than simply reduced synthesis alone