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Here we report that these two oncogenic pathways may not act in concert, but act apparently partially antagonistic at least in human GIC models, potentially accounting for disappointing results with inhibition of either pathway in the clinic 29,30,31 , but also providing new concepts on how to modulate these pathways more efficiently to improve the outcome of glioblastoma

In addition, marked suppression of HCC cell growth was observed both in vitro and in vivo following treatment with a combination of wild-type p53-induced protein phosphatase 1 and PARP inhibitors (138)

& Saltman, P

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If it hurts beyond the initial insertion, thats an indication that something is amiss