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10.1002/alz.70731 Alzheimers Dement

Aging is a big factor, but here is a list of common causes of low glutathione

MOTS-c functions as a powerful metabolic regulator by activating AMPK (AMP-activated protein kinase), a master metabolic switch that enhances glucose uptake, promotes fat oxidation, and improves insulin sensitivity

They can be detected in serum or plasma samples and have been associated with aging, diabetes, Alzheimers disease, neonatal brain injury, and chronic inflammatory conditions [177, 178]