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Low temperatures accelerate metHb denaturation, releasing free hemin or heme and forming hemichromes (Samuel et al., 2020), which tightly bind to the membrane, increasing rigidity, promoting removal signals, like band three aggregates (Pantaleo et al., 2016)

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These variants are now considered to be intermediates within a DNA methylation cycle that involves both the addition and the removal of methylation from DNA (see Figure 2 )