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These changes seem to occur simultaneously with the differential gene expression of loci involved in the negative regulation of leukocyte activation and negative regulation of signal transduction (see connecting edges in Figure 4B )

This negative feedback mechanism is crucial for regulating neuronal activity, as excessive hyperactivity can lead to neuronal death, synaptic loss, and reduced plasticity (Badimon et al., 2020)

Future studies should focus on animal models to assess the pharmacokinetics of CBD derivatives and determine optimal dosing regimens

10.1016/j.jep.2022.115701 140 WangW.LiuY.LiuD.ZhouH.LiY.YuanW.et al (2024a)