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The central mechanism is angiogenesis: the peptide upregulates vascular endothelial growth factor (VEGF) and drives new blood-vessel formation at injury sites, which brings oxygen and nutrients to healing tissue

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Otherwise, there is the milder increases of the pressure in the ligated superior sagittal sinus upon additional volume application in the right external jugular vein or in the inferior caval vein, where in the control rats, the portal/caval hypertension remained unchanged, but contributed to the further raise of the increased pressure in the superior sagittal sinus (Figure 5)

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Clinicians are urged to exercise caution and to proactively counsel patients who may be using these products without disclosure