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While the redox status of TCA enzymes was mainly unchanged (except for malate dehydrogenase at Cys 89 and -ketoglutarate dehydrogenase at Cys 802 ), almost all TCA enzymes were more abundant in tumor cells

Broader context on IV micronutrient delivery is documented in the clinical literature on intravenous micronutrient therapy, which describes the bioavailability advantage of IV delivery while noting where the evidence for routine use is still limited

Treatments that could address redox metabolism abnormalities include methylcobalamin with and without folinic acid in open-label studies and vitamin C and N -acetyl-l-cysteine in DBPC studies

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Understanding the procedure, expected outcomes, aftercare requirements, and treatment costs enables patients to make informed decisions