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The activation of the DAG-PKC pathway increases ROS production via NADPH oxidase, reinforcing OS, while simultaneously disrupting mitochondrial electron transport, uncoupling endothelial nitric oxide synthetase and influencing transcription factors, such as NF-B, which promotes pro-inflammatory signaling (38)

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In periodontal disease, it is recommended to use an adequate well calculated dosage of vitamin C to achieve higher level of healing, minimal bleeding, higher quality of the newly formed tissues and increasing the resistance of tissues to future destruction [12, 62]

Egypt J Pediatr Allergy Immunol