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The generation of NADPH, mainly through the pentose phosphate pathway, is intricately linked to the metabolic state of NAD + /NADH, underscoring the interdependence of these redox couples in maintaining cellular health [11, 12]

They are often more expensive and are usually part of a hybrid system, not a standalone solution replacing all other technologies

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In a phase 1 study, Voxelotor (Oxbryta/GBT440) binds specifically to the N-terminus of the alpha subunit of HbS to stabilize the oxygenated hemoglobin state (Strader et al., 2019), thus reducing the predisposition to sickling