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The BBB employs various transport systems, such as carrier-mediated transport (CMT), receptor-mediated transport (RMT), active efflux transport, vesicular trafficking by transcytosis, and ion transport, to facilitate the entry of essential substances into the brain parenchyma and the efflux of metabolic waste and endogenous neurotoxins [19, 23]

As seen in Table 4, all of the clinical trials testing MET/HGF-directed therapy alongside chemotherapy assessed MET expression using immunohistochemical (IHC) staining of tumour samples

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While these are some of the most promising BPC-157 and TB-500 benefits, research suggests other potential therapeutic applications

doi: 10.1016/j.lfs.2017.08.006