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We identified 22 Cochrane systematic reviews on behavioural interventions, pharmacotherapies, combined behavioural and pharmacotherapy interventions, and other interventions.22 We updated our search in June 2024, and findings on benefits and harms were consistent with results from earlier searches (Appendix 2, available at www.cmaj.ca/lookup/doi/10.1503/cmaj.241584/tab-related-content)

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[9] These symptoms can include cravings for nicotine, anger, irritability, anxiety, depression, impatience, trouble sleeping, restlessness, hunger, weight gain, and difficulty concentrating