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The work of Pickart and colleagues (2012, 2014) showed that GHK-Cu shifts the gene expression profile from an "aged" state toward a more "youthful" state

And then three to six months later, they go back in and the gastroenterologist says, Your gut is healing really well Ive never seen this before. So it can be a clear A-to-B case

This pattern suggests continuous daily Dihexa administration beyond 4-6 weeks without rest periods would likely trigger protective receptor downregulation, reducing compound effectiveness over time

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