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Otros enfoques incluyen el mtodo 5:2, donde las caloras se restringen severamente en dos das no consecutivos por semana, y el ayuno en das alternos

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The SURMOUNT program is composed of multicenter double-blind RCT evaluating the efficacy and safety of OW tirzepatide compared to placebo on top of dietary and physical activity recommendations in patients with obesity or BMI 27 kg/m 2 with 1 weight-related complication 9

The differential metabolites of DFG are mainly involved in pathway of alanine, aspartate, and glutamate metabolism, which is the most important metabolic pathway as it related to the most of other metabolic pathways, followed by arginine and proline metabolism, arginine biosynthesis, glycine, serine and threonine metabolism, glyoxylate and dicarboxylate metabolism, purine metabolism and aminoacyl-tRNA biosynthesis