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For example, surgery to remove a cancerous tumor may also result in the patches fading

ACE2 counters the action of ACE and causes decrease in angiotensin II and increase in angiotensin (17)

These framework substitutions are identified by methods well known in the art, e.g., by modeling of the interactions of the CDR and framework residues to identify framework residues important for antigen binding and sequence comparison to identify unusual framework residues at particular positions