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While extremely concentrated urine may result in greater quantities of certain compounds that obstruct EXOs isolation, very diluted urine can include lesser amounts of EXOs or render their separation more difficult (Tong et al., 2023)

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Second, the strength of tirzepatides evidence is exactly what makes an apples-to-apples ranking against an investigational amylin analog impossible: you cannot fairly rank a fully-approved drug against a candidate whose stand-alone efficacy stops at Phase 2

& Grosveld, G