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Because even modest hills were challenging for a rolling hogshead difficult to ascend, whether powered by man or beast, and dangerous on the down side the road to market tended to find the flattest route possible

Toxins metabolized by CYP1A1: The CYP1A1 enzyme is involved in the metabolism of polycyclic aromatic hydrocarbons (PAH) in the intestines, thus playing a role in smoking -related cancers from the activation of the aromatic hydrocarbons