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Further emphasizing their role as signaling molecules, ROS and particularly H 2 O 2 , are also major regulators of gene expression, as evidenced by extensive genome expression reprogramming under conditions promoting H 2 O 2 accumulation (Queval et al., 2007

Shai, R

The biochemistry of aging

Studies have shown that ASS1 acts as a tumor suppressor because cells with low ASS1 expression could not grow in an environment without arginine [123, 124]