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They inferred that HCO 4 , the oxidizing species, is formed by reaction between H 2 O 2 and CO 2 within the enzyme, enabling it to quickly oxidize the key thiol and redirect carbon flux from glycolysis to the NADPH-generating pentose-phosphate pathway (Winterbourn et al., 2023)

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Consistent with the RNA-seq data, qPCR validation studies detected significantly increased expression of Lgr5 , Hopx , Muc2 and Clu in cIECs isolated from IPA-treated mice at D7 (Supplementary Fig

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