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Patients with COVID-19 may experience a cytokine storm, marked by a significant release of cytokines such as IL-6 and IL-1, resulting in the immune system attacking itself and contributing to fatalities among Sars-Cov-2 patients, see Fig

They run through weight loss, insulin sensitization, and the GLP-1 arm

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Another study in systemic sclerosis found that BH4 administration improved endothelial function and helped with exercise-induced changes in blood flow.[ref] In an animal model of ulcerative colitis, oral BH4 treatment decreased symptoms

Interfaces 10 (37), 3099431007 (2018) D