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However, it is important to keep in mind key limitations, namely that the evidence available is primarily specific to the US population and may not generalize to other populations, and that the small sample size of PWNS who use ECs introduces uncertainty into these results and may fail to detect some significant associations

3), we considered the relative risk (adjusted odds ratio 1.57, 95% CI 1.241.99) of myocardial infarction due to ST identified in the 52-country INTERHEART study [35] (conducted across nine WHO regions) as a valid estimate

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