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How a combination protocol is structured in practice Where the combination is clinically appropriate, the protocol structure follows the available pharmacology of each compound

Aroda VR, Edelstein SL, Goldberg RB, Knowler WC, Marcovina SM, Orchard TJ et al (2016) Long-term metformin use and vitamin B12 deficiency in the Diabetes Prevention Program Outcomes Study

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or participants choosing from session to session which mode (in-person or distance learning) they wish to use