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In the resting state, NMDAR channels are normally blocked by Mg 2+ , but when large amounts of glutamate accumulate, activated AMPAR causes partial depolarization of the postsynaptic membrane, sufficient to clear the Mg 2+ on the NMDAR

The reaction is catalyzed by GST

doi: 10.1093/jn/134.3.489 [DOI] [PubMed] [Google Scholar] 12.Whiting PH, Kalansooriya A, Holbrook I, Haddad F, Jennings PE

Recently, it was demonstrated that diazepam increases the frequency of DA release events while also decreasing their amplitude, suggesting that these two effects are a result of different mechanisms 26

Phosphorylation of p47 phox directs phox homology domain from SH3 domain toward phosphoinositides, leading to phagocyte NADPH oxidase activation