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Flint kids are struggling with a poverty rate of approximately 50%

Because embryonic stem (ES) cells give rise to all the tissues in an organism, mechanisms are in place to avoid the accumulation of DNA to prevent mutations that would transmit to tissues and subsequent generations

Tat triggers oxidative stress in T cells 66,67 , B cells 29 , brain endothelial cells 68,69,70 , neuronal 71,72,73 , microglial 74,75 and astroglial 76 cells

These pathological mechanisms cause significant damage in neurons, glial cells, and endothelial cells, all of which are core nodes in brain injury (Figure 2)

Using the cuprizone mouse model, it was shown that mimicking brain ageing by pharmacological HDAC inhibition causes defective remyelination [202]