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Dentistry Oral

USA 106 , 1015910164 (2009)

Nuclear receptor coactivator 4 (NCOA4) is a crucial molecule for maintaining intracellular and systemic iron homeostasis by specifically recognizing and facilitating the autophagic degradation of ferritin, leading to the release of ferric ions into the unstable iron pool

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The cascade signaling also suffers from oxidative stress in that it affects the activation of protein kinase C (PKC) [37], a serine/threonine kinase pathway that forms part of the mitogenic protein kinase (MAPK) [42] and plays an important role in several intracellular processes such as signal transduction, response to specific hormonal, neuronal and growth factor stimuli [28, 40]