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Over-the-counter supplementation of antioxidants (e.g

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Their depletion has been linked to various neurological disorders, including Parkinson's disease and depression

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Physiological or pharmacological elevation of hepatic FGF21 induces the expression and secretion of insulin-like growth factor-binding protein 1 (IGFBP1) in the liver, IGFBP1 in turn functions as an endocrine hormone by binding to its receptor integrin 1 on osteoclast precursors, and stimulates osteoclast differentiation and bone resorption by potentiating RANKL-induced ERK phosphorylation and NFATc1 activation, thus leading to lower bone mass