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Here SAM acts as a methyl donor which is actually formed with the help of vitamin B12

Niacin or B3 Taking high-dose niacin supplements can result in skin-related allergic reactions, such as extreme facial flushing, also referred to as niacin flush. Flushing causes generalized itching and a burning sensation that is typically limited to the face and chest and lasts 20 to 30 minutes(1)

Vitamin B12 is naturally found in animal-based foods

The rotator cuff consists of a group of muscles and tendons that hold the arm in place and allow for lifting the arm up and overhead

doi: 10.1016/j.carbpol.2018.07.054 [DOI] [PubMed] [Google Scholar] 57.Ahmad N, Ahmad R, Amir M, et al