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At present, the highly recognized pathogenic mechanism is a multiple hit hypothesis, which considers the combined effects of multiple insults on genetically susceptible subjects to induce NAFLD and provides a reasonable explanation for the development of NAFLD (47)

Recently, a combination of BCNU and sorafenib was shown to significantly suppress the in vivo growth of liver cancer by promoting ferroptosis

Hu C, Yang Y, Deng M, Yang L, Shu G, Jiang Q, et al

Oxidative therapies accelerate oxygen metabolism and stimulate the release of oxygen atoms from the bloodstream to the cells

Their results revealed that pups receiving DES exhibited altered uterine development and impaired reproductive function that was associated with changes to the uterine epigenetic landscape (Jefferson et al., 2018)