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AZEpaclitaxome-2 successfully switched the negative charge (~20 mV, at pH 7.4) to positive (~5 mV, at pH 6.5), whereas AZOpaclitaxome-2 failed to do so, substantiating the pKa-based ultra-sensitivity of AZE to mild intratumoral pH (Fig

Clinical applications, therapeutics, and diagnostics An important aspect of the identification of microbiome-derived pathways controlling systemic metabolism is that these pathways might be amenable to therapeutic intervention

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This increase in the density of blood vessels improves the delivery of oxygen, glucose, and other nutrients to brain tissue, supporting its function and aiding in repair and regeneration after injury or age-related decline