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Observational studies Most of the early observational evidence from case-control and nested case-control studies suggested either null or inverse associations between selenium exposure and risk of site-specific cancers (67)

72 A 2021 meta-analysis of 16 RCTs, involving 987 patients with SUDs, found a significant decrease in craving symptoms and a significant improvement in depressive and withdrawal symptoms with NAC compared with control, whilst lower smoking frequency failed to reach statistical significance

But in a sick dog, one or more of these organs may not be able to do its part

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Researchers designing combination protocols should treat the combination as an area of active investigation with mechanistic rationale rather than an established protocol with defined clinical outcomes