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The review by May and den Hartigh focused on the impact of SCFAs on adipose tissue metabolism ( 3.1 MedDiet The MedDiet, originating from the traditional practices of people in the Mediterranean basin, has captured researchers' attention due to its reported health benefits, and is included as a healthy dietary pattern in the 20202025 Dietary Guidelines for Americans ( The Western diet, in contrast to the MedDiet, is a dietary pattern prevalent across many industrialized nations

doi: 10.1172/JCI90350 164 HarmonDBSrikakulapuPKaplanJLOldhamSNMcSkimmingCGarmeyJCet al

ALCAR and KET also activated brainstem nuclei (locus coeruleus, diagonal band, and raphe nuclei) which send aminergic projections to cortical areas and spinal dorsal horns that are involved in pain and mood control (Freo et al., 2010

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Recently, the role of p53 biology in ferroptosis has received increasing interest for novel cancer treatments (Jiang et al., 2015)