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Description

NF1 heterozygosity fosters de novo tumorigenesis but impairs malignant transformation

7 Downregulation of BMPR2 in PAECs induces EndMT by upregulating HMGA1 or activating AKT due to DLL4/Notch1 signaling impairment, leading to a spindle-like cell morphology with increased levels of markers such as -SMA, SM22, calponin, phospho-vimentin, and Slug