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If the change calculated is more than a 100% increase or 50% decrease in either V or CL, the assumptions made about the timing of the sample and the dosing history should be critically examined

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With decreasing kidney function, levels of serum holoTC rise to ensure sufficient holoTC is delivered into cells

The role of CD38 in the tumor microenvironment on glioma progression was also investigated by comparing WT and CD38-deficient mouse models

27 For example, in Malawi, data collection of micronutrient status and other causes of anaemia was added to an existing DHS survey (piggyback approach), where the micronutrient teams followed the main DHS survey teams