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Effects beyond muscle While muscle growth receives the most attention, IGF-1 LR3 affects multiple tissue types throughout the body

In people with obesity, 36 weeks of orforglipron (doses ranging from 12 to 45 mg in a phase 2 trial) resulted in a dose-dependent WL up to 14.7% compared to 2.3% with placebo, with concomitant improvement in cardiometabolic risk factors (Table 2) [25]

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In addition, QCT exhibits a variety of biological effects, including but not limited to antioxidant, anti-inflammatory, anti-cancer, and anti-ischemic, etc 14

Dose-dependent toxicity to healthy tissues and immune system, particularly radiation-sensitive CD8 + T cells in lymphoid organs, compromises systemic anti-tumor responses [17]