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10.1186/s12891-022-05205-z 218 YangC

Decreased prostacyclin, increased thromboxane levels and a reduction in prostacyclin/thromboxane ratio can result in a platelet pro-aggregatory state and systemic vasoconstriction [84], potentially increasing the risk of thromboembolic events and coronary disease

[DOI] [PMC free article] [PubMed] [Google Scholar] 190.Dassa B., London N., Stoddard B.L., Schueler-Furman O., Pietrokovski S

Researchers found that in HYAL2 KO mice, heart valve dilation, atrial dilation, cardiac hypertrophy, ECM deposition, and resulted in increased mortality [200]

The ability of nitric oxide to lower intraocular pressure is dependent on guanylyl cyclase