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This paper is a comprehensive prospective casecontrol study that first reported the high prevalence of the metabolic syndrome in patients with HS, an observation most striking among young patients

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doi: 10.1158/1541-7786.MCR-20-0827 210 AbdelmagidSARickardJAMcDonaldWJThomasLNTooCK

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FGF21 also appears to mediate some of the effects of hepatic glucagon and thyroid hormone signaling, since both activation of glucagon receptor (GCGR) (106) and thyroid hormone receptor- (TR-) (107) induce secretion of FGF21 by hepatocytes

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