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Why oral glutathione fails: the biochemistry The active site of glutathione is the sulfhydryl group (SH) on cysteine

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90 Isolated arthritis is the presenting symptom in ~25% of patients and may be misdiagnosed as RA

Liposomes can bypass some of these "gatekeepers" by merging directly with the cell membrane, delivering the glutathione directly into the intracellular space

However, its lack of specificity remains a major limitation: NfL levels can rise following surgical procedures or systemic stress and thus cannot be used in isolation to infer neuroprotective efficacy