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Conclusions The publication of the 2024 NICE guidelines on B 12 deficiency represents progress but falls short by proposing to rename pernicious anaemia with autoimmune gastritis. This change does not adequately address the distinct nature of PA as an advanced stage of AIG, characterised by IF deficiency requiring lifelong B 12 treatment

Figure 31

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they can indicate that the skin has lost its elasticity or that the sebum production is not being regulated properly

And the underlying causes of autoimmune disorders can be grouped into the following two categories: Genetics: If your mother has or has had hypothyroidism, you have a 50 percent chance of developing it