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Controlled endocrine studies further demonstrate that: ACTH levels remain unchanged despite significant GH pulses Corticosterone (rodent analog of cortisol) does not increase proportionally to GH output Repeated administration maintains endocrine stability across dosing cycles Importantly, earlier secretagogues frequently produced concurrent elevations in GH, ACTH, and prolactin, complicating the interpretation of recovery-focused outcomes [1]

Many environmental factors are known to modulate NRA (Tischner, 2000)

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Bernhardsson, S., Klintberg, I